Am J Med. 2012 Oct;125(10):974-80.
Total antioxidant capacity from diet and risk of myocardial infarction: a prospective cohort of women.
Rautiainen S, Levitan EB, Orsini N, Åkesson A, Morgenstern R, Mittleman MA, Wolk A.
Source
Division of Nutritional Epidemiology, Institute of Environmental Medicine,
Karolinska Institutet, Stockholm, Sweden. susanne.rautiainen@ki.se
Abstract
BACKGROUND:
There are no previous studies investigating the effect of all dietary
antioxidants in relation to myocardial infarction. The total antioxidant
capacity of diet takes into account all antioxidants and synergistic effects
between them. The aim of this study was to examine how total antioxidant
capacity of diet and antioxidant-containing foods were associated with incident
myocardial infarction among middle-aged and elderly women.
METHODS:
In the population-based prospective Swedish Mammography Cohort of 49-83-year-old
women, 32,561 were cardiovascular disease-free at baseline. Women completed a
food-frequency questionnaire, and dietary total antioxidant capacity was
calculated using oxygen radical absorbance capacity values. Information on
myocardial infarction was identified from the Swedish Hospital Discharge and the
Cause of Death registries. Hazard ratios (HR) and 95% confidence intervals (CI)
were calculated using Cox proportional hazard models.
RESULTS:
During the follow-up (September 1997-December 2007), we identified 1114 incident
cases of myocardial infarction (321,434 person-years). In multivariable-adjusted
analysis, the HR for women comparing the highest quintile of dietary total
antioxidant capacity to the lowest was 0.80 (95% CI, 0.67-0.97; P for
trend=0.02). Servings of fruit and vegetables and whole grains were
nonsignificantly inversely associated with myocardial infarction.
CONCLUSIONS:
These data suggest that dietary total antioxidant capacity, based on fruits,
vegetables, coffee, and whole grains, is of importance in the prevention of
myocardial infarction.
Copyright © 2012 Elsevier Inc. All rights reserved.
PMID: 22998880 [PubMed - indexed for MEDLINE]