Am J Epidemiol. 2012 Oct 1;176 Suppl 7:S106-13.
Physical activity reduces salt sensitivity of blood pressure: the Genetic Epidemiology Network of Salt Sensitivity Study.
Rebholz CM, Gu D, Chen J, Huang JF, Cao J, Chen JC, Li J, Lu F, Mu J, Ma J, Hu D, Ji X, Bazzano LA, Liu D, He J; GenSalt Collaborative Research Group.
Source
Department of Epidemiology, School of Public Health and Tropical Medicine,
Tulane University, New Orleans, Louisiana 70112, USA.
Abstract
Salt sensitivity of blood pressure (BP) is influenced by genetic and
environmental factors. A dietary feeding study was conducted from October 2003
to July 2005 that included a 7-day low-sodium intervention (51.3 mmol sodium/day)
followed by a 7-day high-sodium intervention (307.8 mmol sodium/day) among 1,906
individuals who were 16 years of age or older and living in rural northern
China. Salt sensitivity of BP was defined as mean BP change from the low-sodium
intervention to the high-sodium intervention. Usual physical activity during the
past 12 months was assessed at baseline using a standard questionnaire. The
multivariable-adjusted means of systolic BP responses to high-sodium
intervention were 5.21 mm Hg (95% confidence interval (CI): 4.55, 5.88), 4.97 mm
Hg (95% CI: 4.35, 5.59), 5.02 mm Hg (95% CI: 4.38, 5.67), and 3.96 mm Hg (95% CI:
3.29, 4.63) among participants from the lowest to the highest quartiles of
physical activity, respectively (P = 0.003 for linear trend). The
multivariable-adjusted odds ratio of high salt sensitivity of systolic BP was
0.66 (95% CI: 0.49, 0.88) for persons in the highest quartile of physical
activity compared with those in the lowest quartile. Physical activity is
significantly, independently, and inversely related to salt sensitivity of BP
and may be particularly effective in lowering BP among salt-sensitive
individuals.
PMID: 23035134 [PubMed - indexed for MEDLINE]
PMCID: PMC3530366