Asia Pac J Clin Nutr. 2013 Jan;22(1):32-40.
The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio.
Sofi F, Giorgi G, Cesari F, Gori AM, Mannini L, Parisi G, Casini A, Abbate R, Gensini GF, Poli BM.
Source
Department of Clinica and Experimental Medicine, Thrombosis Centre, Florence,
Italy. francescosofi@gmail.com
Abstract
The aim of this study was to evaluate the effect of consuming gilthead sea bream
fillets, with different n-6/ n-3 ratios, on atherosclerotic biomarkers. Twenty
healthy subjects were included in a randomised single-blinded cross-over trial.
Participants were randomized into 2 groups, both of which received approximately
630 g per week of gilthead sea bream fed with either 100% fishmeal (FM) or
partial replacement with plant proteins (PP) over two consecutive 10 week
periods, respectively. Group A consumed firstly the FM fillets followed by the
PP fillets, whereas the reverse order was adopted for group B. Group A reported
a significant decrease of 29.3% (? = -26 mg/dL) in total cholesterol after the
first phase of the intervention, before returning to baseline levels after the
dietary intervention with fish fed with PP. Similarly, in group A, both
LDL-cholesterol and triglycerides decreased significantly by 21.6% (? = -19 mg/dL)
and 11.7% (? = -10.7 mg/dL), respectively, before increasing again after the
intervention. Improvements in the inflammatory cytokines, interleukin-6 and -8
were also noted. Moreover, whole blood viscosity appeared significantly improved
in group A, as seen by a significant increase of 7.59% (? = +4.59 mPA) for
erythrocyte filtration rate. In conclusion, similar EPA+DHA content with
different n- 6/n-3 ratio fish flesh intake was shown to have varied affects on
lipid, inflammatory and haemorheological parameters in a group of healthy
subjects.
PMID: 23353608 [PubMed - indexed for MEDLINE]