Br J Cancer. 2014 Mar 4;110(5):1328-33.
Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study.
Xiao Q, Freedman ND, Ren J, Hollenbeck AR, Abnet CC, Park Y.
Abstract
BACKGROUND:
Nutrients in the one-carbon metabolism pathway may be involved in carcinogenesis. Few cohort studies have investigated the intakes of folate and related nutrients in relation to gastric and esophageal cancer.
METHODS:
We prospectively examined the association between self-reported intakes of folate, methionine, vitamin B6, and vitamin B12 and gastric and esophageal cancer in 492,293 men and women.
RESULTS:
We observed an elevated risk of esophageal squamous cell carcinoma with low intake of folate (relative risk (95% confidence interval): Q1 vs Q3, 1.91 (1.17, 3.10)), but no association with high intake. Folate intake was not associated with esophageal adenocarcinoma, gastric cardia adenocarcinoma, or non-cardia gastric adenocarcinoma. The intakes of methionine, vitamin B6, and vitamin B12 were not associated with esophageal and gastric cancer.
CONCLUSION:
Low intake of folate was associated with increased risk of esophageal squamous cell carcinoma.
PMID: 24481406 [PubMed - indexed for MEDLINE]