Int J Cancer. 2013 Feb 1;132(3):617-24.
Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition.
Rohrmann S, Linseisen J, Nöthlings U, Overvad K, Egeberg R, Tjřnneland A, Boutron-Ruault MC, Clavel-Chapelon F, Cottet V, Pala V, Tumino R, Palli D, Panico S, Vineis P, Boeing H, Pischon T, Grote V, Teucher B, Khaw KT, Wareham NJ, Crowe FL, Goufa I, Orfanos P, Trichopoulou A, Jeurnink SM, Siersema PD, Peeters PH, Brustad M, Engeset D, Skeie G, Duell EJ, Amiano P, Barricarte A, Molina-Montes E, Rodríguez L, Tormo MJ, Sund M, Ye W, Lindkvist B, Johansen D, Ferrari P, Jenab M, Slimani N, Ward H, Riboli E, Norat T, Bueno-de-Mesquita HB.
Source
Division of Cancer Epidemiology and Prevention, Institute of Social and
Preventive Medicine, University of Zurich, Zurich, Switzerland.
sabine.rohrmann@ifspm.uzh.ch
Abstract
Pancreatic cancer is the fourth most common cause of cancer death worldwide with
large geographical variation, which implies the contribution of diet and
lifestyle in its etiology. We examined the association of meat and fish
consumption with risk of pancreatic cancer in the European Prospective
Investigation into Cancer and Nutrition (EPIC). A total of 477,202 EPIC
participants from 10 European countries recruited between 1992 and 2000 were
included in our analysis. Until 2008, 865 nonendocrine pancreatic cancer cases
have been observed. Calibrated relative risks (RRs) and 95% confidence intervals
(CIs) were computed using multivariable-adjusted Cox hazard regression models.
The consumption of red meat (RR per 50 g increase per day = 1.03, 95% CI =
0.93-1.14) and processed meat (RR per 50 g increase per day = 0.93, 95% CI =
0.71-1.23) were not associated with an increased pancreatic cancer risk. Poultry
consumption tended to be associated with an increased pancreatic cancer risk (RR
per 50 g increase per day = 1.72, 95% CI = 1.04-2.84); however, there was no
association with fish consumption (RR per 50 g increase per day = 1.22, 95% CI =
0.92-1.62). Our results do not support the conclusion of the World Cancer
Research Fund that red or processed meat consumption may possibly increase the
risk of pancreatic cancer. The positive association of poultry consumption with
pancreatic cancer might be a chance finding as it contradicts most previous
findings.
Copyright © 2012 UICC.
PMID: 22610753 [PubMed - indexed for MEDLINE]