Pol Merkur Lekarski. 2013 Jan;34(199):54-7.
[Genistein in chemoprevention and treatment].
[Article in Polish]
Tarkowski M, Kokoci?ska M, Latocha M.
Source
Slaski Uniwersytet Medyczny w Katowicach, Zaklad Biologii Komórki.
Abstract
Genistein is a natural compound which occurs in Asian diet, rich in soy products.
It has a wide spectrum of activity, expressed both in protecting cells from
malignant transformation, reducing proliferation of tumor cells and stimulating
apoptosis. In the other hand, genistein also prevents from some of the side
effects manifesting in menopausal estrogen deficiency also being a good research
object in this field. It has been shown, among others effect of genistein on:
the level of free radicals and reactive oxygen species in the body, the
metabolism of carcinogenic factors, cell cycle progression, initiation of
apoptosis, angiogenesis, inflammatory processes and immune response. To achieve
the desired therapeutic effect it is crucial to determine genistein dose
titration in order to obtain an appropriate concentration in the tissues of
phytohormone and duration of therapy.
PMID: 23488287 [PubMed - indexed for MEDLINE]