Am J Clin Nutr. 2012 Dec;96(6):1398-408.
Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Zamora-Ros R, Agudo A, Luján-Barroso L, Romieu I, Ferrari P, Knaze V, Bueno-de-Mesquita HB, Leenders M, Travis RC, Navarro C, Sánchez-Cantalejo E, Slimani N, Scalbert A, Fedirko V, Hjartĺker A, Engeset D, Skeie G, Boeing H, Förster J, Li K, Teucher B, Agnoli C, Tumino R, Mattiello A, Saieva C, Johansson I, Stenling R, Redondo ML, Wallström P, Ericson U, Khaw KT, Mulligan AA, Trichopoulou A, Dilis V, Katsoulis M, Peeters PH, Igali L, Tjřnneland A, Halkjćr J, Touillaud M, Perquier F, Fagherazzi G, Amiano P, Ardanaz E, Bredsdorff L, Overvad K, Ricceri F, Riboli E, González CA.
Source
Unit of Nutrition, Environment, and Cancer, Cancer Epidemiology Research
Programme, Catalan Institute of Oncology, Barcelona, Spain.
rzamora@iconcologia.net
Abstract
BACKGROUND:
Several experimental studies have suggested potential anticarcinogenic effects
of flavonoids, although epidemiologic evidence for the impact of dietary
flavonoids on risk of gastric cancer (GC) is limited.
OBJECTIVE:
We investigated the association between intake of dietary flavonoids and lignans
and incident GC.
DESIGN:
The study followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European
countries who participated in the European Prospective Investigation into Cancer
and Nutrition (EPIC) study. Validated dietary questionnaires and lifestyle
information were collected at baseline. A food-composition database on
flavonoids and lignans was compiled by using data from USDA and Phenol-Explorer
databases.
RESULTS:
During an average follow-up of 11 y, 683 incident GC cases (57.8% men) were
mostly validated by a panel of pathologists and used in this analysis. We
observed a significant inverse association between total flavonoid intake and GC
risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the continuous variable after
log? transformation) but not in men (HR: 0.97; 95% CI: 0.85, 1.09). In women,
significant inverse associations with GC risk were also observed for intakes of
some flavonoid subgroups (anthocyanidins, flavonols, flavones, and flavanols),
particularly with intestinal type tumors for total flavonoid and flavanol
intakes (P-heterogeneity < 0.1). After stratification by smoking status and sex,
there was no significant heterogeneity in these associations between ever- and
never-smokers.
CONCLUSION:
Total dietary flavonoid intake is associated with a significant reduction in the
risk of GC in women.
PMID: 23076618 [PubMed - indexed for MEDLINE]