J Natl Cancer Inst. 2012 Aug 8;104(15):1173-81.
Vitamin intake and liver cancer risk: a report from two cohort studies in China.
Zhang W, Shu XO, Li H, Yang G, Cai H, Ji BT, Gao J, Gao YT, Zheng W, Xiang YB.
Source
State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute,
Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai
200032, China.
Abstract
BACKGROUND:
Epidemiologic studies on the relationship between vitamin intake and liver
cancer risk are sparse and inconsistent.
METHODS:
We evaluated vitamin intake from diet and supplements and risk of liver cancer
in 132,837 women and men from China who were recruited into the Shanghai Women's
Health Study from 1997 to 2000 or the Shanghai Men's Health Study from 2002 to
2006. In-person interviews, using a validated food-frequency questionnaire, were
conducted to collect data on dietary habits. Follow-up consisted of in-person
surveys and record linkage. Hazard ratios and 95% confidence intervals were
estimated using Cox proportional hazard models with adjustment for potential
confounders to compare liver cancer risk among participants with high vs low
vitamin intake. All statistical tests were two-sided.
RESULTS:
After excluding the first 2 years of follow-up, 267 participants (including 118
women and 149 men) developed liver cancer during an average of 10.9 (Shanghai
Women's Health Study) or 5.5 (Shanghai Men's Health Study) years of follow-up.
Dietary vitamin E intake was inversely associated with liver cancer risk
(P(trend) = .01), as was vitamin E supplement use (hazard ratio = 0.52, 95%
confidence interval = 0.30 to 0.90). This association was consistent among
participants with and without self-reported liver disease or a family history of
liver cancer. Vitamin C and multivitamin use was associated with increased risk
among participants with self-reported liver disease or family history of liver
cancer, whereas intake of vitamin C and other vitamins from dietary sources was
unrelated to liver cancer risk.
CONCLUSIONS:
Vitamin E intake, either from diet or supplements, may reduce the risk of liver
cancer.
PMID: 22811438 [PubMed - indexed for MEDLINE]