Br J Nutr. 2013 Jan 14;109(1):118-28.
The effect of raw vegetable and fruit intake on thyroid cancer risk among women: a case-control study in South Korea.
Jung SK, Kim K, Tae K, Kong G, Kim MK.
Source
Department of Preventive Medicine, College of Medicine, Hanyang University,
Medical School Building A-Room 512, 17 Haengdang Dong, Sungdong Gu, Seoul
133-791, Republic of Korea.
Abstract
Thyroid cancer is the most common cancer among Korean women. However, there are
few data on dietary factors related to thyroid cancer risk. The objective of the
present study was to evaluate the association between raw vegetables and fruits
intake and thyroid cancer in a case-control study. We included 111
histologically confirmed malignant thyroid cancer cases and 115 benign cases.
Controls who did not have nodules in thyroid ultrasonography were matched to
cases by age (± 2 years). Food and nutrient intakes were estimated using a
quantitative FFQ with 121 items. Conditional logistic regression analysis was
used to obtain OR and corresponding 95 % CI. The intake of total vegetables was
not associated with malignant thyroid cancer, but inversely associated with
benign cases. High raw vegetable intake was inversely associated with thyroid
cancer risk both in malignant and benign cases (P for trend = 0·01 in both
malignant and benign cases). Among fruits, persimmon intake had an inverse
association with thyroid cancer risk in both malignant and benign cases (P for
trend = 0·06 in malignant cases; P for trend = 0·01 in benign cases) and
tangerine intake had an inverse association in malignant cases (P for trend =
0·03). The frequency of consumption of raw vegetables and persimmon also had a
consistent inverse association in both malignant and benign cases. These results
suggest that high consumption of raw vegetables, persimmons and tangerines may
decrease thyroid cancer risk and help prevent early-stage thyroid cancer.
PMID: 22455656 [PubMed - indexed for MEDLINE]